MONOSODIUM SALT ACETAZOLAMIDE
\mˌɒnə͡ʊsˈə͡ʊdi͡əm sˈɒlt ˈasɪtˌazəlˌama͡ɪd], \mˌɒnəʊsˈəʊdiəm sˈɒlt ˈasɪtˌazəlˌamaɪd], \m_ˌɒ_n_əʊ_s_ˈəʊ_d_iə_m s_ˈɒ_l_t ˈa_s_ɪ_t_ˌa_z_ə_l_ˌa_m_aɪ_d]\
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One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
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