CLEAR CELL MENINGIOMAS
\klˈi͡ə sˈɛl mˌɛnɪŋɡɪˈə͡ʊməz], \klˈiə sˈɛl mˌɛnɪŋɡɪˈəʊməz], \k_l_ˈiə s_ˈɛ_l m_ˌɛ_n_ɪ_ŋ_ɡ_ɪ__ˈəʊ_m_ə_z]\
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A relatively common neoplasm of the central nervous system that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and spinal canal. They tend to present in the fourth to sixth decades of life with signs indicative of a slowly progressive mass lesion. Specific clinical manifestations depend on the location of the tumor, but may include INTRACRANIAL HYPERTENSION, cranial neuropathies, ataxia, and other focal neurologic signs. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.