ISCHEMIC OPTIC NEUROPATHIES
\ɪskˈiːmɪk ˈɒptɪk njuːɹˈɒpəθɪz], \ɪskˈiːmɪk ˈɒptɪk njuːɹˈɒpəθɪz], \ɪ_s_k_ˈiː_m_ɪ_k ˈɒ_p_t_ɪ_k n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ_z]\
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Ischemic injury to the optic nerve which usually affects the optic disk (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLI; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.