Definitions of c erbB 2 Protein

  1. A cell surface protein- tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor ( RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB- 3 receptor ( RECEPTOR, ERBB- 3) and the erbB- 4 receptor. Activation of the erbB- 2 receptor occurs during heterodimer formation with a ligand- bound erbB receptor family members. EC 2. 7. 11.-.