Definitions of c erbB 2 Protein

  1.   A cell surface protein tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas It has extensive homology to and can heterodimerize with the EGF receptor RECEPTOR EPIDERMAL GROWTH FACTOR the erbB 3 receptor RECEPTOR ERBB 3 and the erbB 4 receptor Activation of the erbB 2 receptor occurs during heterodimer formation with a ligand bound erbB receptor family members EC 2 7 11