Definitions of c erbB 2 Proto Oncogenes

  1. The erbB- 2 gene is a proto- oncogene that codes for the erbB- 2 receptor ( RECEPTOR, ERBB- 2), a protein with structural features simular to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog ( v- erbB) which is a truncated form of the chicken erbB gene found in the avian erythoblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c- erbB- 2 gene is located at 17q21. 2.