C ERBB 1 PROTO ONCOGENE
\sˈiː ˈɜːb bˈiː wˈɒn pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːn], \sˈiː ˈɜːb bˈiː wˈɒn pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːn], \s_ˈiː_ ˈɜː_b b_ˈiː w_ˈɒ_n p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n]\
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The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.