C ERBB 1 PROTEIN
\sˈiː ˈɜːb bˈiː wˈɒn pɹˈə͡ʊtiːn], \sˈiː ˈɜːb bˈiː wˈɒn pɹˈəʊtiːn], \s_ˈiː_ ˈɜː_b b_ˈiː w_ˈɒ_n p_ɹ_ˈəʊ_t_iː_n]\
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A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell. EC 2.7.11.-.
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