C ERBA PROTO ONCOGENES
\sˈiː ˈɜːb ɐ pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːnz], \sˈiː ˈɜːb ɐ pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːnz], \s_ˈiː_ ˈɜː_b ɐ p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
Sort: Oldest first
-
Retrovirus-associated DNA sequences (ERYTHROBLASTOSIS VIRUS, AVIAN, hence erbA) originally isolated from the avian erythroblastosis virus. The c-erbA proto-oncogene encodes the thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA proto-oncogenes have been identified, erbA-alpha and erbA-beta, each giving rise to at least two proteins. erbA-alpha is located at 17q21 on the long arm of chromosome 17. erbA-beta is located at 3p24 on the short arm of chromosome 3. The v-erbA oncogene potentiates cell transformation through inhibition of spontaneous differentiation of cells already transformed by the v-erbB gene and eliminates growth requirements of transformed erythroblasts.
By DataStellar Co., Ltd
Word of the day
Mustagh Range
- a mountain range in northern Kashmir; an extension of the Hindu Kush; contains 2nd highest peak