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Definitions of c erbA Genes

  1.   Retrovirus associated DNA sequences ERYTHROBLASTOSIS VIRUS AVIAN hence erbA originally isolated from the avian erythroblastosis virus The c erbA proto oncogene encodes the thyroid hormone receptors RECEPTORS THYROID HORMONE Two distinct c erbA proto oncogenes have been identified erbA alpha and erbA beta each giving rise to at least two proteins erbA alpha is located at 17q21 on the long arm of chromosome 17 erbA beta is located at 3p24 on the short arm of chromosome 3 The v erbA oncogene potentiates cell transformation through inhibition of spontaneous differentiation of cells already transformed by the v erbB gene and eliminates growth requirements of transformed erythroblasts