Definitions of c erbA Proteins
Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c- erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c- erbA proteins act as growth suppressors. The c- erbA proteins are encoded by at least two genes, c- erbA alpha and c- erbA beta. Each of these has two isoforms. Mutations in the ligand- binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.