NEUROLEPTIC MALIGNANT SYNDROMES
\njˌuːɹə͡ʊlˈɛptɪk məlˈɪɡnənt sˈɪndɹə͡ʊmz], \njˌuːɹəʊlˈɛptɪk məlˈɪɡnənt sˈɪndɹəʊmz], \n_j_ˌuː_ɹ_əʊ_l_ˈɛ_p_t_ɪ_k m_ə_l_ˈɪ_ɡ_n_ə_n_t s_ˈɪ_n_d_ɹ_əʊ_m_z]\
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A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49 (9):1163-72)
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