NEUROGENIC SARCOMAS
\njˌuːɹə͡ʊd͡ʒˈɛnɪk sɑːkˈə͡ʊməz], \njˌuːɹəʊdʒˈɛnɪk sɑːkˈəʊməz], \n_j_ˌuː_ɹ_əʊ_dʒ_ˈɛ_n_ɪ_k s_ɑː_k_ˈəʊ_m_ə_z]\
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A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65 (2):164-72)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.