HISTOCOMPATIBILITY ANTIGENS CLASS II
\hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪd͡ʒˌɛnz klˈas ɹˌə͡ʊmən tˈuː], \hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪdʒˌɛnz klˈas ɹˌəʊmən tˈuː], \h_ˌɪ_s_t_ə_k_ˌɒ_m_p_ɐ_t_ɪ_b_ˈɪ_l_ɪ_t_i_ ˈa_n_t_ɪ_dʒ_ˌɛ_n_z k_l_ˈa_s ɹ_ˌəʊ_m_ə_n_ t_ˈuː]\
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Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
By DataStellar Co., Ltd
Nearby Words
- histocompatibility
- histocompatibility antigen
- histocompatibility antigen dna probes
- histocompatibility antigens
- histocompatibility antigens class i
- Histocompatibility Antigens Class II
- histocompatibility complex
- histocompatibility complices
- histocompatibility testing
- histocompatibility testings
- histocyte