HISTOCOMPATIBILITY ANTIGENS CLASS I
\hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪd͡ʒˌɛnz klˈas ˈa͡ɪ], \hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪdʒˌɛnz klˈas ˈaɪ], \h_ˌɪ_s_t_ə_k_ˌɒ_m_p_ɐ_t_ɪ_b_ˈɪ_l_ɪ_t_i_ ˈa_n_t_ɪ_dʒ_ˌɛ_n_z k_l_ˈa_s ˈaɪ]\
Sort: Oldest first
-
Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.
By DataStellar Co., Ltd
Word of the day
Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.
Nearby Words
- histocompatibilities
- histocompatibility
- histocompatibility antigen
- histocompatibility antigen dna probes
- histocompatibility antigens
- Histocompatibility Antigens Class I
- histocompatibility antigens class ii
- histocompatibility complex
- histocompatibility complices
- histocompatibility testing
- histocompatibility testings