HISTOCOMPATIBILITY ANTIGEN DNA PROBES
\hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪd͡ʒˌɛn dˌiːˌɛnˈe͡ɪ pɹˈə͡ʊbz], \hˌɪstəkˌɒmpɐtɪbˈɪlɪti ˈantɪdʒˌɛn dˌiːˌɛnˈeɪ pɹˈəʊbz], \h_ˌɪ_s_t_ə_k_ˌɒ_m_p_ɐ_t_ɪ_b_ˈɪ_l_ɪ_t_i_ ˈa_n_t_ɪ_dʒ_ˌɛ_n d_ˌiː__ˌɛ_n_ˈeɪ p_ɹ_ˈəʊ_b_z]\
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DNA probes specific for the human leukocyte antigen genes, which represent the major histocompatibility determinants in humans. The four known loci are designated as A, B, C, and D. Specific antigens are identified by a locus notation and number, e.g., HLA-A11. The inheritance of certain HLA alleles is associated with increased risk for certain diseases (e.g., insulin-dependent diabetes mellitus).
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Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.