HEPARIN BINDING GROWTH FACTOR, CLASS I
\hˈɛpəɹˌɪn bˈa͡ɪndɪŋ ɡɹˈə͡ʊθ fˈaktə], \hˈɛpəɹˌɪn bˈaɪndɪŋ ɡɹˈəʊθ fˈaktə], \h_ˈɛ_p_ə_ɹ_ˌɪ_n b_ˈaɪ_n_d_ɪ_ŋ ɡ_ɹ_ˈəʊ_θ f_ˈa_k_t_ə]\
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A 17 kD single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
By DataStellar Co., Ltd
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Nearby Words
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