EOSINOPHILIA MYALGIA SYNDROME
\ˌiːəsˌɪnəfˈɪli͡ə ma͡ɪˈald͡ʒə sˈɪndɹə͡ʊm], \ˌiːəsˌɪnəfˈɪliə maɪˈaldʒə sˈɪndɹəʊm], \ˌiː__ə_s_ˌɪ_n_ə_f_ˈɪ_l_iə m_aɪ__ˈa_l_dʒ_ə s_ˈɪ_n_d_ɹ_əʊ_m]\
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A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSPINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26 (6):788-93)
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Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.