V SIS ONCOGENE
\vˈiː sˈɪs ˈɒnkə͡ʊd͡ʒˌiːn], \vˈiː sˈɪs ˈɒnkəʊdʒˌiːn], \v_ˈiː s_ˈɪ_s ˈɒ_n_k_əʊ_dʒ_ˌiː_n]\
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Retrovirus-associated DNA sequences (v-sis) originally isolated from the simian sarcoma virus (SSV). The proto-oncogene c-sis codes for a growth factor which is the B chain of PLATELET-DERIVED GROWTH FACTOR. v-sis or overexpression of c-sis causes tumorigenesis. The human sis gene is located at 22q12.3-13.1 on the long arm of chromosome 22.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.