What does sis mean?we found 2 entries for the meaning of sis
 

Sis \Sis\, n. A colloquial abbreviation of Sister.

Source: Webster's Revised Unabridged Dictionary (1913)
 

 

Sis \Sis\, n. Six. See Sise. [Obs.]

--Chaucer.

Source: Webster's Revised Unabridged Dictionary (1913)
 

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