Definitions of v abl Oncogene

  1. Retrovirus- associated DNA sequences ( abl) originally isolated from the Abelson murine leukemia virus ( Ab- MuLV). The proto- oncogene abl ( c- abl) codes for a protein that is a member of the tyrosine kinase family. The human c- abl gene is located at 9q34. 1 on the long arm of chromosome 9. It is activated by translocation to bcr on chromosome 22 in chronic myelogenous leukemia.