[v_ˈiː s_ˌiː_dʒ_ˌeɪ_d_ˈiː __v_ˈeə_ɹ_iə_n_t k_r_j_ˈuː_t_s_f_ɛ_l_t dʒ_ˈa_k_ɒ_b d_ɪ_z_ˈiː_z], [vˈiː sˌiːd͡ʒˌe͡ɪdˈiː vˈe͡əɹi͡ənt krjˈuːtsfɛlt d͡ʒˈakɒb dɪzˈiːz], [vˈiː sˌiːdʒˌeɪdˈiː vˈeəɹiənt krjˈuːtsfɛlt dʒˈakɒb dɪzˈiːz]
Definitions of V CJD (Variant Creutzfeldt Jakob Disease)
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A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD ( potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. ( From N Engl J Med, 1998 Dec 31; 339( 27))
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