PYKNO EPILEPSY
\pˈɪknə͡ʊ ˈɛpɪlˌɛpsi], \pˈɪknəʊ ˈɛpɪlˌɛpsi], \p_ˈɪ_k_n_əʊ ˈɛ_p_ɪ_l_ˌɛ_p_s_i]\
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A childhood seizure disorder characterized by rhythmic electrical brain discharges of geneneralized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the seizure. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.