LAMBERT EATON MYASTHENIC MYOPATHIC SYNDROME
\lˈambət ˈiːtən mˌa͡ɪɐsθˈɛnɪk mˌa͡ɪəpˈaθɪk sˈɪndɹə͡ʊm], \lˈambət ˈiːtən mˌaɪɐsθˈɛnɪk mˌaɪəpˈaθɪk sˈɪndɹəʊm], \l_ˈa_m_b_ə_t ˈiː_t_ə_n m_ˌaɪ__ɐ_s_θ_ˈɛ_n_ɪ_k m_ˌaɪ_ə_p_ˈa_θ_ɪ_k s_ˈɪ_n_d_ɹ_əʊ_m]\
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An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
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Nearby Words
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