HEREDITARY X LINKED RECESSIVE SPASTIC PARAPLEGIA
\hɪɹˈɛdɪtəɹi ˈɛks lˈɪŋkt ɹɪsˈɛsɪv spˈastɪk pˌaɹəplˈiːd͡ʒə], \hɪɹˈɛdɪtəɹi ˈɛks lˈɪŋkt ɹɪsˈɛsɪv spˈastɪk pˌaɹəplˈiːdʒə], \h_ɪ_ɹ_ˈɛ_d_ɪ_t_ə_ɹ_i_ ˈɛ_k_s l_ˈɪ_ŋ_k_t ɹ_ɪ_s_ˈɛ_s_ɪ_v s_p_ˈa_s_t_ɪ_k p_ˌa_ɹ_ə_p_l_ˈiː_dʒ_ə]\
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A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64 (1):61-6; Curr Opin Neurol 1997 Aug;10 (4):313-8)
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Nearby Words
- hereditary tyrosinemia
- hereditary tyrosinemia, type i
- hereditary tyrosinemia, type ii
- hereditary tyrosinemia, type iii
- hereditary tyrosinemias
- Hereditary X linked Recessive Spastic Paraplegia
- hereditary, spastic paraplegia, autosomal dominant
- hereditary, spastic paraplegia, x linked recessive
- hereditary, type iii, motor and sensory neuropathy
- hereditary, type vii, motor and sensory neuropathy
- hereditation