EPIDERMAL GROWTH FACTOR RECEPTOR GENES
\ˌɛpɪdˈɜːmə͡l ɡɹˈə͡ʊθ fˈaktə ɹɪsˈɛptə d͡ʒˈiːnz], \ˌɛpɪdˈɜːməl ɡɹˈəʊθ fˈaktə ɹɪsˈɛptə dʒˈiːnz], \ˌɛ_p_ɪ_d_ˈɜː_m_əl ɡ_ɹ_ˈəʊ_θ f_ˈa_k_t_ə ɹ_ɪ_s_ˈɛ_p_t_ə dʒ_ˈiː_n_z]\
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The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
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Nearby Words
- epidermal cell derived thymocyte activating factor
- epidermal cyst
- epidermal cysts
- epidermal growth factor
- epidermal growth factor receptor
- Epidermal Growth Factor Receptor Genes
- epidermal growth factor receptor kinase
- epidermal growth factor receptor protein tyrosine kinase
- epidermal growth factor related transforming growth factor
- epidermal growth factor urogastrone
- epidermal growth factors