EPIDERMAL CELL DERIVED THYMOCYTE ACTIVATING FACTOR
\ˌɛpɪdˈɜːmə͡l sˈɛl dɪɹˈa͡ɪvd θˈa͡ɪməsˌa͡ɪt ˈaktɪvˌe͡ɪtɪŋ fˈaktə], \ˌɛpɪdˈɜːməl sˈɛl dɪɹˈaɪvd θˈaɪməsˌaɪt ˈaktɪvˌeɪtɪŋ fˈaktə], \ˌɛ_p_ɪ_d_ˈɜː_m_əl s_ˈɛ_l d_ɪ_ɹ_ˈaɪ_v_d θ_ˈaɪ_m_ə_s_ˌaɪ_t ˈa_k_t_ɪ_v_ˌeɪ_t_ɪ_ŋ f_ˈa_k_t_ə]\
Definitions of EPIDERMAL CELL DERIVED THYMOCYTE ACTIVATING FACTOR
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A soluble factor produced by monocytes, macrophages, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. IL-1 consists of two distinct forms, IL-1 alpha and IL-1 beta which perform the same functions but are distinct proteins. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. The factor is distinct from INTERLEUKIN-2.
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- A malignant arising nuclear layer retina that is most primary eye in children. The tumor tends to occur early childhood or infancy present at birth. majority are sporadic, but condition may be transmitted as autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS; STRABISMUS; visual loss represent common clinical characteristics this condition. (From DeVita et al., Cancer: Principles Practice Oncology, 5th ed, p2104)