CYTOCHROME C OXIDASE SUBUNIT IV
\sˈa͡ɪtəkɹˌə͡ʊm sˈiː ˈɒksɪdˌe͡ɪs sˈʌbjuːnˌɪt ɹˌə͡ʊmən fˈɔː], \sˈaɪtəkɹˌəʊm sˈiː ˈɒksɪdˌeɪs sˈʌbjuːnˌɪt ɹˌəʊmən fˈɔː], \s_ˈaɪ_t_ə_k_ɹ_ˌəʊ_m s_ˈiː_ ˈɒ_k_s_ɪ_d_ˌeɪ_s s_ˈʌ_b_j_uː_n_ˌɪ_t ɹ_ˌəʊ_m_ə_n_ f_ˈɔː]\
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The terminal oxidase of the respiratory chain. It collects electrons that are transferred from reduced CYTOCHROME C and donates them to molecular oxygen, which is then reduced to water. It is composed of CYTOCHROME A and CYTOCHROME B, two copper atoms, and 13 different protein subunits, three of which are encoded by the mitochondrial DNA. It is also called complex IV of the respiratory chain. (from Scriver et al., The Metabolic & Molecular Bases of Inherited Disease, 8th ed, p2261 and p2368)
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