OMEGA PROTEIN, TOPOISOMERASE I
\ə͡ʊmˈe͡ɪɡə pɹˈə͡ʊtiːn], \əʊmˈeɪɡə pɹˈəʊtiːn], \əʊ_m_ˈeɪ_ɡ_ə p_ɹ_ˈəʊ_t_iː_n]\
Sort: Oldest first
-
Bacterial enzymes of the DNA TOPOISOMERASES TYPE I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.