PLATIDIAM
\plˈatɪdˌi͡əm], \plˈatɪdˌiəm], \p_l_ˈa_t_ɪ_d_ˌiə_m]\
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An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
By DataStellar Co., Ltd
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Harmar, Josiah
- (1753-1813), born in Philadelphia, served during Revolutionary War, attaining rank of lieutenant-colonel, and was commander-in-chief the U.S. army from 1789 to 1792.