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A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily. EC 2.7.10.-
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Pyramidal Cells
- Projection neurons in cerebral cortex hippocampus. Pyramidal cells a pyramid-shaped soma with apex apical dendrite pointed toward pial surface and other dendrites an axon emerging from base. The axons may have local collaterals but also project outside their cortical region.