COAGULATION FACTOR XIIA
\kə͡ʊˌaɡjʊlˈe͡ɪʃən fˈaktə zˈɪiə], \kəʊˌaɡjʊlˈeɪʃən fˈaktə zˈɪiə], \k_əʊ_ˌa_ɡ_j_ʊ_l_ˈeɪ_ʃ_ə_n f_ˈa_k_t_ə z_ˈɪ__i__ə]\
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Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
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