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A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.

The proteinsplitting ferment of the pancreas, it differs from pepsin in that it acts better in a slightly alkaline medium such as it finds in the intestine. It is used in medicine in cases of intestinal indigestion in doses of gr. 8-15 (0.5-1.0) in keratin coated pills or capsules; it is also used to peptonize milk, and as a solvent of diphtheritic membrane, and has been given by hypodermic injection in connection with amylopsin in the treatment of cancer.

A pancreatic ferment.

An enzyme of pancreatic juice ; a similar enzyme of various plants and animals.

The main protolytic ferment of the pancreatic secretion.

A soluble proteolytic ferment which may be separated from the pancreatic juice and which acts in many respects like pepsin, but differs from it in being most potent in a neutral or slightly alkaline medium.