TUBERCULOUS HYPERTROPHIC PACHYMENINGITIS
\tjˈuːbəkjˌʊləs hˌa͡ɪpətɹˈɒfɪk pˌat͡ʃa͡ɪmˌɛnɪnd͡ʒˈa͡ɪtɪs], \tjˈuːbəkjˌʊləs hˌaɪpətɹˈɒfɪk pˌatʃaɪmˌɛnɪndʒˈaɪtɪs], \t_j_ˈuː_b_ə_k_j_ˌʊ_l_ə_s h_ˌaɪ_p_ə_t_ɹ_ˈɒ_f_ɪ_k p_ˌa_tʃ_aɪ_m_ˌɛ_n_ɪ_n_dʒ_ˈaɪ_t_ɪ_s]\
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A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
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