PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA
\pɹəɡɹˈɛsɪv ɛkstˈɜːnə͡l ˌɒfθɐlməplˈiːd͡ʒə], \pɹəɡɹˈɛsɪv ɛkstˈɜːnəl ˌɒfθɐlməplˈiːdʒə], \p_ɹ_ə_ɡ_ɹ_ˈɛ_s_ɪ_v ɛ_k_s_t_ˈɜː_n_əl ˌɒ_f_θ_ɐ_l_m_ə_p_l_ˈiː_dʒ_ə]\
Sort: Oldest first
-
A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- progressive chorea, chronic hereditary (huntington)
- progressive chorea, hereditary, chronic (huntington)
- progressive deafness
- progressive discipline
- progressive emphysematous necrosis
- Progressive External Ophthalmoplegia
- progressive external ophthalmoplegias
- progressive facial atrophy
- progressive facial hemiatrophies
- progressive facial hemiatrophy
- progressive hemi of the face