PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS
\pɹˈa͡ɪməɹi pɹəɡɹˈɛsɪv mˈʌltɪpə͡l skləɹˈə͡ʊsɪs], \pɹˈaɪməɹi pɹəɡɹˈɛsɪv mˈʌltɪpəl skləɹˈəʊsɪs], \p_ɹ_ˈaɪ_m_ə_ɹ_i p_ɹ_ə_ɡ_ɹ_ˈɛ_s_ɪ_v m_ˈʌ_l_t_ɪ_p_əl s_k_l_ə_ɹ_ˈəʊ_s_ɪ_s]\
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A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
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