ISOCITRATE DEHYDROGENASE
\ˈa͡ɪsəsˌɪtɹe͡ɪt dˌiːha͡ɪdɹˈə͡ʊd͡ʒne͡ɪs], \ˈaɪsəsˌɪtɹeɪt dˌiːhaɪdɹˈəʊdʒneɪs], \ˈaɪ_s_ə_s_ˌɪ_t_ɹ_eɪ_t d_ˌiː_h_aɪ_d_ɹ_ˈəʊ_dʒ_n_eɪ_s]\
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An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
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