EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN TYROSINE KINASE
\ˌɛpɪdˈɜːmə͡l ɡɹˈə͡ʊθ fˈaktə ɹɪsˈɛptə pɹˈə͡ʊtiːn tˈa͡ɪɹəsˌa͡ɪn kˈɪne͡ɪs], \ˌɛpɪdˈɜːməl ɡɹˈəʊθ fˈaktə ɹɪsˈɛptə pɹˈəʊtiːn tˈaɪɹəsˌaɪn kˈɪneɪs], \ˌɛ_p_ɪ_d_ˈɜː_m_əl ɡ_ɹ_ˈəʊ_θ f_ˈa_k_t_ə ɹ_ɪ_s_ˈɛ_p_t_ə p_ɹ_ˈəʊ_t_iː_n t_ˈaɪ_ɹ_ə_s_ˌaɪ_n k_ˈɪ_n_eɪ_s]\
Definitions of EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN TYROSINE KINASE
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A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell. EC 2.7.11.-.
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