COMPLEMENTARY DISTRIBUTION
\kˌɒmplɪmˈɛntəɹi dˌɪstɹɪbjˈuːʃən], \kˌɒmplɪmˈɛntəɹi dˌɪstɹɪbjˈuːʃən], \k_ˌɒ_m_p_l_ɪ_m_ˈɛ_n_t_ə_ɹ_i d_ˌɪ_s_t_ɹ_ɪ_b_j_ˈuː_ʃ_ə_n]\
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.