COMPLEMENTARY COLOR
\kˌɒmplɪmˈɛntəɹi kˈʌlə], \kˌɒmplɪmˈɛntəɹi kˈʌlə], \k_ˌɒ_m_p_l_ɪ_m_ˈɛ_n_t_ə_ɹ_i k_ˈʌ_l_ə]\
Word of the day
ATP Binding Cassette, Sub Family B Proteins
- A subfamily transmembrane the superfamily TRANSPORTERS that closely related in GLYCOPROTEIN. When overexpressed, function as dependent efflux pumps able extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.