C SIS PROTO ONCOGENES
\sˈiː sˈɪs pɹˈə͡ʊtə͡ʊ ˈɒnkə͡ʊd͡ʒˌiːnz], \sˈiː sˈɪs pɹˈəʊtəʊ ˈɒnkəʊdʒˌiːnz], \s_ˈiː s_ˈɪ_s p_ɹ_ˈəʊ_t_əʊ ˈɒ_n_k_əʊ_dʒ_ˌiː_n_z]\
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Retrovirus-associated DNA sequences (v-sis) originally isolated from the simian sarcoma virus (SSV). The proto-oncogene c-sis codes for a growth factor which is the B chain of PLATELET-DERIVED GROWTH FACTOR. v-sis or overexpression of c-sis causes tumorigenesis. The human sis gene is located at 22q12.3-13.1 on the long arm of chromosome 22.
By DataStellar Co., Ltd
