Definitions of c sis Gene

  1. Retrovirus- associated DNA sequences ( v- sis) originally isolated from the simian sarcoma virus ( SSV). The proto- oncogene c- sis codes for a growth factor which is the B chain of PLATELET- DERIVED GROWTH FACTOR. v- sis or overexpression of c- sis causes tumorigenesis. The human sis gene is located at 22q12. 3- 13. 1 on the long arm of chromosome 22.