PREKALLIKREIN ACTIVATOR
\pɹɪkˈalɪkɹˌiːn ˈaktɪvˌe͡ɪtə], \pɹɪkˈalɪkɹˌiːn ˈaktɪvˌeɪtə], \p_ɹ_ɪ_k_ˈa_l_ɪ_k_ɹ_ˌiː_n ˈa_k_t_ɪ_v_ˌeɪ_t_ə]\
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Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
By DataStellar Co., Ltd
Nearby Words
- prejudicially
- prejudicialness
- prejudicing
- prejudicious
- prekallikrein
- Prekallikrein Activator
- prekinins
- preknowledge
- prel-ate
- prelacies
- prelacrymal