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Definitions of v erbA Proteins

  1.   Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus They are truncated versions of c erbA the thyroid hormone receptor RECEPTORS THYROID HORMONE that have retained both the DNA binding and hormone binding domains Mutations in the hormone binding domains abolish the transcriptional activation function v erbA acts as a dominant repressor of c erbA inducing transformation by disinhibiting proliferation