V ERBA PROTEINS
\vˈiː ˈɜːb ɐ pɹˈə͡ʊtiːnz], \vˈiː ˈɜːb ɐ pɹˈəʊtiːnz], \v_ˈiː_ ˈɜː_b ɐ p_ɹ_ˈəʊ_t_iː_n_z]\
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Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
By DataStellar Co., Ltd
