Definitions of v erbA Proteins

  1. Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c- erbA, the thyroid hormone receptor ( RECEPTORS, THYROID HORMONE) that have retained both the DNA- binding and hormone- binding domains. Mutations in the hormone- binding domains abolish the transcriptional activation function. v- erbA acts as a dominant repressor of c- erbA, inducing transformation by disinhibiting proliferation.