Definitions of v erbB Oncogenes

  1.   The proto oncogene c erbB 1 codes for the epidermal growth factor receptor Its name originates from the viral homolog v erbB which was isolated from an avian erythroblastosis virus AEV where it was contained as a fragment of the chicken c ErbB 1 gene lacking the amino terminal ligand binding domain Overexpression of erbB 1 genes occurs in a wide range of tumors commonly squamous carcinomas of various sites and less commonly adenocarcinomas The human c erbB 1 gene is located in the chromosomal region 7p14 and 7p12