Definitions of v erbB Oncogenes
The proto- oncogene c- erbB- 1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v- erbB which was isolated from an avian erythroblastosis virus ( AEV) where it was contained as a fragment of the chicken c- ErbB- 1 gene lacking the amino- terminal ligand- binding domain. Overexpression of erbB- 1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c- erbB- 1 gene is located in the chromosomal region 7p14 and 7p12.