TERMINAL COMPLEMENT COMPLEX
\tˈɜːmɪnə͡l kˈɒmplɪmənt kˈɒmplɛks], \tˈɜːmɪnəl kˈɒmplɪmənt kˈɒmplɛks], \t_ˈɜː_m_ɪ_n_əl k_ˈɒ_m_p_l_ɪ_m_ə_n_t k_ˈɒ_m_p_l_ɛ_k_s]\
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The assembly of complement plasma glycoproteins C5b, C6, C7, C8, and polymeric C9 as a group on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade.
By DataStellar Co., Ltd
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