T4 THYROID HORMONE
\tˈiː fˈɔː θˈa͡ɪɹɔ͡ɪd hˈɔːmə͡ʊn], \tˈiː fˈɔː θˈaɪɹɔɪd hˈɔːməʊn], \t_ˈiː f_ˈɔː θ_ˈaɪ_ɹ_ɔɪ_d h_ˈɔː_m_əʊ_n]\
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The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
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