PENTOBARBITONE
\pˈɛntəbˌɑːbɪtˌə͡ʊn], \pˈɛntəbˌɑːbɪtˌəʊn], \p_ˈɛ_n_t_ə_b_ˌɑː_b_ɪ_t_ˌəʊ_n]\
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A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.