NEUROLOGIC PLUMBISM
\njˌuːɹəlˈɒd͡ʒɪk plˈʌmbɪzəm], \njˌuːɹəlˈɒdʒɪk plˈʌmbɪzəm], \n_j_ˌuː_ɹ_ə_l_ˈɒ_dʒ_ɪ_k p_l_ˈʌ_m_b_ɪ_z_ə_m]\
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Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, CHILDHOOD) and adults (LEAD POISONING, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.