NEONATAL CEREBRAL LEUKOMALACIA
\nˈiːə͡ʊnˌe͡ɪtə͡l səɹˈiːbɹə͡l lˌuːkəmɐlˈe͡ɪʃə], \nˈiːəʊnˌeɪtəl səɹˈiːbɹəl lˌuːkəmɐlˈeɪʃə], \n_ˈiː__əʊ_n_ˌeɪ_t_əl s_ə_ɹ_ˈiː_b_ɹ_əl l_ˌuː_k_ə_m_ɐ_l_ˈeɪ_ʃ_ə]\
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Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and COGNITIVE DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
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