MUCOPOLYSACCHARIDOSIS IV
\mjuːkˈɒpəlˌɪsɐkˌɑːɹɪdˈə͡ʊsɪs ɹˌə͡ʊmən fˈɔː], \mjuːkˈɒpəlˌɪsɐkˌɑːɹɪdˈəʊsɪs ɹˌəʊmən fˈɔː], \m_j_uː_k_ˈɒ_p_ə_l_ˌɪ_s_ɐ_k_ˌɑː_ɹ_ɪ_d_ˈəʊ_s_ɪ_s ɹ_ˌəʊ_m_ə_n_ f_ˈɔː]\
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Genetic disorder of mucopolysaccharide metabolism characterized by skeletal abnormalities, joint instability, development of cervical myelopathy, and excessive urinary keratan sulfate. There are two biochemically distinct forms, each due to a deficiency of a different enzyme.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.